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				<font color="#666666" size="4" face="Arial">Computational 
				Biology Tools</font></a></td>
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				<a href="Default.htm" style="text-decoration: none">
				<font color="#757575">Create Epitome</font></a><br>
				Details</font></span></td>
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						<a href="Default.htm">
						<font face="Arial" size="2" color="#000000">Tool</font></a></b></td>
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						<font color="#000000">References</font></a></font></b></td>
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						<font color="#000000">Code</font></a></font></b></td>
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		<br/>
		<span class="style1"><font face="Arial" size="4" color="#0000FF">
		Overview</font></span><p align="justify"><span class="style1">
						<font size="3" face="Arial" color="#757575">This tool 
		models genetic diversity by summarizing a large input dataset into an 
		epitome, a short sequence capturing many overlapping subsequences from 
		the dataset.</font></span></p>
		<p align="justify"><span class="style1"><font face="Arial" color="#757575">For example, 
		applying the tool to modeling the diversity of HIV, the epitome produces 
		relatively small vaccine immunogens covering a large number of immune 
		system targets known as epitopes. Our experiments have shown that the 
		epitome includes more epitopes than other vaccine designs of similar 
		length, including cocktails of consensus strains, phylogenetic tree 
		centers, and observed strains.</font></span></p>
		<p align="justify"><span class="style1"><font size="3" face="Arial" color="#757575">The 
		tool optimizes greedily, that is, it </font>
		<font face="Arial" color="#757575">iteratively increases the length of 
		the epitome by appending a patch (possibly with overlap) from the data 
		which maximally reduces the ratio of the sum of the patch weights of the 
		included patches to the length of the epitome. The process can be 
		stopped once the desired length is achieved (rather than when the entire 
		set of patches is included as in the superstring problem).</font></span></p>
		<p><span class="style1"><font face="Arial" size="4" color="#0000FF">
		Input Format</font></span></p>
		<p><span class="style1"><font size="3" face="Arial" color="#757575">The 
		tool accepts input in two formats.</font></span></p>
		<p><span class="style1"><font face="Arial" color="#0000FF">First, a text table:</font></span></p>
		<table border="0" cellpadding="0" cellspacing="0" style="border-collapse: collapse; width: 153px">
			<colgroup>
				<col width="64" span="2" style="width:48pt">
			</colgroup>
			<tr height="20" style="height:15.0pt">
				<td height="20" style="height: 15.0pt; width: 98px; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				Patch</td>
				<td style="width: 53px; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				Weight</td>
			</tr>
			<tr height="20" style="height:15.0pt">
				<td height="20" style="height: 15.0pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px" width="98">
				&nbsp;NKIVRMYSP</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px" width="53">
				167</td>
			</tr>
			<tr height="20" style="height:15.0pt">
				<td height="20" style="height: 15.0pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px" width="98">
				&nbsp;LNKIVRMYS</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px" width="53">
				167</td>
			</tr>
			<tr height="20" style="height:15.0pt">
				<td height="20" style="height: 15.0pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px" width="98">
				&nbsp;PQDLNTMLN</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px" width="53">
				166</td>
			</tr>
			<tr height="20" style="height:15.0pt">
				<td height="20" style="height: 15.0pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px" width="98">
				&nbsp;QDLNTMLNT</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px" width="53">
				166</td>
			</tr>
			<tr height="20" style="height:15.0pt">
				<td height="20" style="height: 15.0pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px" width="98">
				&nbsp;GATPQDLNT</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px" width="53">
				166</td>
			</tr>
			<tr height="20" style="height:15.0pt">
				<td height="20" style="height: 15.0pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px" width="98">
				&nbsp;EGATPQDLN</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px" width="53">
				166</td>
			</tr>
			<tr height="20" style="height:15.0pt">
				<td height="20" style="height: 15.0pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px" width="98">
				&nbsp;ATPQDLNTM</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px" width="53">
				165</td>
			</tr>
			<tr height="20" style="height:15.0pt">
				<td height="20" style="height: 15.0pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px" width="98">
				&nbsp;TPQDLNTML</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px" width="53">
				165</td>
			</tr>
		</table>
		<p><span class="style1"><font face="Arial" color="#757575">Separate the 
		columns with space, tab, or comma. The headers are required.</font></span></p>
		<p><span class="style1"><font face="Arial" color="#757575">The first 
		column contains patches for possible inclusion in the epitome. The 
		second column gives their relative weights.</font></span></p>
		<p><span class="style1"><font face="Arial" color="#757575">This format 
		is easily created via a spreadsheet program such as Excel. Transfer data 
		to the tool either with cut (cntl-C) and paste (cntl-V) or by saving the 
		spreadsheet in text format and using the tool's &quot;Upload File&quot; button.
		</font></span></p>
		<p><span class="style1"><font face="Arial" color="#0000FF">The tool also 
		accepts a second forma</font><font face="Arial" color="#757575">t: free text without weights. For example,</font></span></p>
		<table border="0" cellpadding="0" cellspacing="0" style="border-collapse: collapse; width: 192px">
			<colgroup>
				<col width="64" style="width:48pt">
			</colgroup>
			<tr height="20" style="height:15.0pt">
				<td height="20" style="height: 15.0pt; width: 190px; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				<span class="style1"><font face="Arial" color="#757575">Twinkle, 
				twinkle, little star;<br>
				How I wonder what you are.</font></span></td>
			</tr>
		</table>
		<p><span class="style1"><font face="Arial" size="4" color="#0000FF">
		Output Format</font></span></p>
		<p><span class="style1"><font face="Arial" color="#757575">When &quot;Show 
		Only Last&quot; is unchecked, the tool shows the sequence of epitomes 
		created. This output is tab-delimited and suitable for cutting (cntl-A,cntl-C) 
		and pasting (cntl-V) into a spreadsheet such as Excel.</font></span></p>
		<table border="0" cellpadding="0" cellspacing="0" width="320" style="border-collapse: collapse; width: 240pt">
			<colgroup>
				<col width="64" span="5" style="width:48pt">
			</colgroup>
			<tr height="20" style="height:15.0pt">
				<td height="20" width="64" style="height: 15.0pt; width: 48pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				Method</td>
				<td width="64" style="width: 48pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				AminoAcidLength</td>
				<td width="64" style="width: 48pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				numComponents</td>
				<td width="64" style="width: 48pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				coverage</td>
				<td width="64" style="width: 48pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				Vaccine</td>
			</tr>
			<tr height="20" style="height:15.0pt">
				<td height="20" style="height: 15.0pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				Greedy</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				9</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				1</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				0.125753</td>
				<td style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				LNKIVRMYS</td>
			</tr>
			<tr height="20" style="height:15.0pt">
				<td height="20" style="height: 15.0pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				Greedy</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				10</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				1</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				0.251506</td>
				<td style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				LNKIVRMYSP</td>
			</tr>
			<tr height="20" style="height:15.0pt">
				<td height="20" style="height: 15.0pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				Greedy</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				17</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				1</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				0.376506</td>
				<td style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				PQDLNTMLNKIVRMYSP</td>
			</tr>
			<tr height="20" style="height:15.0pt">
				<td height="20" style="height: 15.0pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				Greedy</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				18</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				1</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				0.500753</td>
				<td style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				TPQDLNTMLNKIVRMYSP</td>
			</tr>
			<tr height="20" style="height:15.0pt">
				<td height="20" style="height: 15.0pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				Greedy</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				19</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				1</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				0.625</td>
				<td style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				ATPQDLNTMLNKIVRMYSP</td>
			</tr>
			<tr height="20" style="height:15.0pt">
				<td height="20" style="height: 15.0pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				Greedy</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				20</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				1</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				0.75</td>
				<td style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				GATPQDLNTMLNKIVRMYSP</td>
			</tr>
			<tr height="20" style="height:15.0pt">
				<td height="20" style="height: 15.0pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				Greedy</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				21</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				1</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				0.875</td>
				<td style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				EGATPQDLNTMLNKIVRMYSP</td>
			</tr>
			<tr height="20" style="height:15.0pt">
				<td height="20" style="height: 15.0pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				Greedy</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				30</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				2</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				1</td>
				<td style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				EGATPQDLNTMLNKIVRMYSP,QDLNTMLNT</td>
			</tr>
		</table>
		<p>&nbsp;</p>
		<table border="0" cellpadding="0" cellspacing="0" width="320" style="border-collapse: collapse; width: 240pt">
			<colgroup>
				<col width="64" span="5" style="width:48pt">
			</colgroup>
			<tr height="20" style="height:15.0pt">
				<td height="20" width="64" style="height: 15.0pt; width: 48pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				Method</td>
				<td width="64" style="width: 48pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				AminoAcidLength</td>
				<td width="64" style="width: 48pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				numComponents</td>
				<td width="64" style="width: 48pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				coverage</td>
				<td width="64" style="width: 48pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				Vaccine</td>
			</tr>
			<tr height="20" style="height:15.0pt">
				<td height="20" style="height: 15.0pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				Greedy</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				7</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				1</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				0.3</td>
				<td style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				TWINKLE</td>
			</tr>
			<tr height="20" style="height:15.0pt">
				<td height="20" style="height: 15.0pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				Greedy</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				7</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				1</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				0.3</td>
				<td style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				TWINKLE</td>
			</tr>
			<tr height="20" style="height:15.0pt">
				<td height="20" style="height: 15.0pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				Greedy</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				10</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				2</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				0.4</td>
				<td style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				TWINKLE,HOW</td>
			</tr>
			<tr height="20" style="height:15.0pt">
				<td height="20" style="height: 15.0pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				Greedy</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				13</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				2</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				0.5</td>
				<td style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				WHATWINKLE,HOW</td>
			</tr>
			<tr height="20" style="height:15.0pt">
				<td height="20" style="height: 15.0pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				Greedy</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				12</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				1</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				0.5</td>
				<td style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				HOWHATWINKLE</td>
			</tr>
			<tr height="20" style="height:15.0pt">
				<td height="20" style="height: 15.0pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				Greedy</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				15</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				2</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				0.6</td>
				<td style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				HOWHATWINKLE,YOU</td>
			</tr>
			<tr height="20" style="height:15.0pt">
				<td height="20" style="height: 15.0pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				Greedy</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				18</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				3</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				0.7</td>
				<td style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				HOWHATWINKLE,YOU,ARE</td>
			</tr>
			<tr height="20" style="height:15.0pt">
				<td height="20" style="height: 15.0pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				Greedy</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				20</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				3</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				0.8</td>
				<td style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				HOWHATWINKLE,YOU,STARE</td>
			</tr>
			<tr height="20" style="height:15.0pt">
				<td height="20" style="height: 15.0pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				Greedy</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				26</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				4</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				0.9</td>
				<td style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				HOWHATWINKLE,YOU,STARE,LITTLE</td>
			</tr>
			<tr height="20" style="height:15.0pt">
				<td height="20" style="height: 15.0pt; color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				Greedy</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				32</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				5</td>
				<td align="right" style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				1</td>
				<td style="color: black; font-size: 11.0pt; font-weight: 400; font-style: normal; text-decoration: none; font-family: Calibri, sans-serif; text-align: general; vertical-align: bottom; white-space: nowrap; border: 1px solid; padding-left: 1px; padding-right: 1px; padding-top: 1px">
				HOWHATWINKLE,YOU,STARE,LITTLE,WONDER</td>
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		<p>&nbsp;</div></td>
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		<td width="23">&nbsp;</td>
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